Mast Cells are found in connective tissue. Some disorders of idiopathic mast cell activation include anaphylaxis, chronic urticaria, intrinsic asthma and others. Mast Cell Activation Disorders are not able to be clinically distinguished from Mastocytosis. There are other factors known to be asociated with MCA, for example hypothyroidism, autoimmunity and neoplastic disease.
Systemic mastocytosis is a disorder caused by a genetic mutation that results in an excessive number of mast cells in the body. Mast cells normally help protect you from disease and help in wound healing by releasing substances such as histamine and leukotrienes. But with systemic mastocytosis, excess mast cells can build up in the skin, around blood vessels, in the respiratory, gastrointestinal and urinary tracts, or in reproductive organs. When triggered, these mast cells release substances that can overwhelm the body and result in symptoms such as facial flushing, itching, a rapid heartbeat, abdominal cramps, lightheadedness or even loss of consciousness. Common triggers include alcohol, temperature changes, spicy foods and certain medications.
The Mastocytosis Society Inc describes Mastocytosis as:
Scholarly article: “Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.” Gerhard J Molderings,1 Stefan Brettner,2 Jürgen Homann,3 and Lawrence B Afrin4 J Hematol Oncol. 2011; 4: 10. Published online 2011 Mar 22. doi: 10.1186/1756-8722-4-10
Perhaps ask for serum Tryptase to be tested, to see if it is high…..
“Dysautonomia International Research Update: POTS, EDS, MCAS Genetics Research update on a gene associated with a POTS/dysautonomia, MCAS, EDS phenotype”, presented during Dysautonomia International’s 2015 Conference by Dr. Joshua Milner, Chief, Genetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health. https://vimeo.com/142039306
Dr. Maitland’s 2014 EDNF Conference video: http://eds-nyc.com/tag/dr-maitland/
Dr Maitland’s slides about MCAS: http://ednf.org/sites/default/files/Anne%20Maitland.pdf
Pamphlet to learn more and to teach others about MCAS: http://mastocytosis.ca/MSC%20Information%20Pamphlet.pdf
Dr. Afrin, “A concise, practical guide to diagnostic assessment for mast cell activation disease”, World Journal of Hematology, 2014: http://www.wjgnet.com/2218-6204/pdf/v3/i1/1.pdf
Pictures of dermatographic urticaria: http://en.m.wikipedia.org/wiki/Dermatographic_urticaria
See also: http://www.mastocytosis.ca/masto.htm